Board Certified Psychiatrist

Ernest Graypel, MD, MHA

Principal Investigator

Ernest A. Graypel, MD, MHA, is a board-certified psychiatrist and Principal Investigator with 20+ years of clinical experience across psychiatry, geriatric psychiatry, cognitive impairment, long-term care, and advanced psychiatric treatments. Before returning to direct clinical practice, he built and operated a home health care business and three assisted living facilities, giving him an unusually practical view of patient care, site operations, and complex psychiatric populations.

Dr. Graypel has authored several publications, including two presented internationally, as well as Graypel’s Review of Dementias and Adult Cognitive Impairments for Non-Psychiatrists. His research site is supported by experienced staff, psychometric raters, and a large database of research-naive patients across mood, anxiety, cognitive, and related CNS disorders.

"I'm excited to leverage Tekton's resources to help bring new medicines to the CNS market, because gaps still remain in treatments for mood disorders, anxiety disorders, and dementia."

Ernest Graypel, MD

Research Site(s)

20+
years in practice

Capabilites & Expertise

Qualifications

  • Board-certified psychiatrist and Principal Investigator with 20+ years of psychiatric practice
  • Owner and practicing psychiatrist with Community and Long-Term Care Psychiatry, LLC
  • Author of several publications, including two presented at international conferences
  • Author of Graypel’s Review of Dementias and Adult Cognitive Impairments for Non-Psychiatrists
  • Former statewide psychiatric director for the Missouri Department of Corrections
  • Former medical director of behavioral health at Saint Anthony’s Hospital
  • Clinical associate professor at A.T. Still University
  • Large database of research-naive psychiatric and CNS patients
  • Experienced staff and psychometric raters across MDD, anxiety, bipolar disorder, and other mood disorders

Education

  • Medical school: Saratov State Medical University in the former Soviet Union
  • Psychiatry residency: Saint Louis University School of Medicine; University of Missouri-Kansas City School of Medicine

Location(s)

Therapeutic Experience

  • Substance use disorders
  • Attention-deficit/hyperactivity disorder (ADHD)
  • Alzheimer’s disease
  • Anorexia nervosa
  • Anxiety disorders
  • Autism spectrum disorder
  • Bipolar I and II disorders
  • Major depressive disorder (MDD)
  • Obsessive-compulsive disorder (OCD)
  • Panic disorder
  • Posttraumatic stress disorder (PTSD)
  • Schizoaffective disorder
  • Schizophrenia
  • Social anxiety disorder
  • Treatment-resistant depression (TRD)

Get to Know Ernest Graypel, MD, MHA

Ernest Graypel, MD

Dr. Ernest A. Graypel is a board-certified psychiatrist with extensive experience in clinical psychiatry, behavioral health leadership, medical education, and clinical research. He earned his medical degree from Saratov State Medical University and completed his psychiatry residency through the Center for Behavioral Medicine in Kansas City and Saint Louis University School of Medicine. He also holds a Master of Health Administration from Webster University.

Dr. Graypel serves as Medical Director of Community and Long-Term Care Psychiatry, Medical Director at Harris House Foundation, and Psychiatric Director at Kindred St. Louis Hospital. He is certified as a Nursing Home Administrator by the Missouri Department of Health and Senior Services and is a Fellow of the American College of Healthcare Administrators (FACHCA). His clinical practice spans outpatient psychiatry, hospital consultation, and long-term care, where he provides individualized, evidence-based treatment that integrates medication management with psychotherapy.

In addition to his clinical practice, Dr. Graypel is a Principal Investigator with Tekton Research, leading clinical trials evaluating investigational treatments for psychiatric and neurologic conditions. Through clinical research, he helps advance new treatment options while providing eligible patients access to innovative therapies.

Dr. Graypel also serves as a Clinical Adjunct Associate Professor at A.T. Still University. In 2022, he was named Preceptor of the Year by A.T. Still University students at Mercy South Hospital. Previously, he held statewide and regional psychiatric leadership roles overseeing psychiatric services within the Missouri Department of Corrections.

A published author and frequent regional, national, and international speaker, Dr. Graypel wrote Graypel’s Review of Dementias and Adult Cognitive Impairments for Non-Psychiatrists and has developed several registered psychiatric screening tools. He has also been recognized as a Lifetime Member of Top Doctors of America for his professional achievements and commitment to patient care. Dr. Graypel remains dedicated to advancing the field of psychiatry through exceptional patient care, medical education, and clinical research.

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